Articles
Link to Google Scholar
35. Emergence of dynamic instability by hybridizing synthetic self-assembled dipeptide fibers with surfactant micelles
Shogo Torigoe, Kazutoshi Nagao, Ryou Kubota, Itaru Hamachi.
J. Am. Chem. Soc. 146, 5799–5805 (2024). DOI: 10.1021/jacs.3c14565
34. Cell-like synthetic supramolecular soft materials realized in multicomponent, non-/out-of-equilibrium dynamic systems
Ryou Kubota, Itaru Hamachi
Adv. Sci. 11, 2306830 (2024). DOI:10.1002/advs.202306830
Perspective article, open access
33. Supramolecular–polymer composite hydrogels: from in situ network observation to functional properties
Ryou Kubota
Bull. Chem. Soc. Jpn. 96, 802–812 (2023). DOI: 10.1246/bcsj.20230129
Review article, open access
32. Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time
Ryou Kubota, Taro Hiroi, Yuriki Ikuta, Yuchong Liu, Itaru Hamachi
J. Am. Chem. Soc. 145, 18316–18328 (2023). DOI: 10.1021/jacs.3c03793
ChemRxiv preprint. DOI: 10.26434/chemrxiv-2023-hjqc9
highlighted by JACS spotlights
31. Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions
Keisuke Nakamura, Ryou Kubota, Itaru Hamachi
Nature Commun. 14, 1696 (2023). DOI: 10.1038/s41467-023-37412-0
ChemRxiv DOI: 10.26434/chemrxiv-2022-7tkt5
Repository at Kyoto U. https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/281524
highlighted in Kyoto University, Graduate School of Engineering
30. Temporal stimulus dynamics drive differentiation of a synthetic dipeptide-based coacervate
Ryou Kubota, Shogo Torigoe, Itaru Hamachi
J. Am. Chem. Soc. 144, 15155–15164 (2022). DOI: 10.1021/jacs.2c05101
Repository at Kyoto U. https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/276054
ChemRxiv, DOI: 10.26434/chemrxiv-2022-bp028
29. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue
Kento Ojima, Wataru Kakegawa, Masayuki Ito, Yuta Miura, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Tokiwa Yamasaki, Eriko Miura, Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka
Nature Commun. 13, 3167 (2022). DOI: 10.1038/s41467-022-30828-0
bioRxiv, DOI: 10.1101/2021.10.01.462737
28. Shape-selective one-step synthesis of branched gold nanoparticles on the crystal surface of redox-active PdII macrocycles
Yutaro Yamashita, Shohei Tashiro, Yoshiki Ishii, Takayuki Uchihashi, Nobuyuki Matsushita, Ryou Kubota, Mitsuhiko Shionoya
Dalton Trans. 51,1318–1324 (2022). DOI: 10.1039/d1dt03973c
highlighted in a front cover
27. Photo-triggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-sorting Double Network Hydrogel
Keisuke Nakamura, Wataru Tanaka, Kei Sada, Ryou Kubota, Takuma Aoyama, Kenji Urayama, Itaru Hamachi
J. Am. Chem. Soc. 143, 19532–19541 (2021). DOI: 10.1021/jacs.1c09172
26. Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies
Ryou Kubota, Wataru Tanaka, Itaru Hamachi
Chem. Rev. 121, 14281–14347 (2021). DOI: 10.1021/acs.chemrev.0c01334
25. Face-selective adsorption of a prochiral compound on the chiral pore-surface of metal-macrocycle framework (MMF) directed towards stereoselective reactions
Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya
Faraday Discuss. 225, 197–209 (2021). DOI: 10.1039/D0FD00019A
24. In situ real-time confocal imaging of a self-assembling peptide-grafted polymer showing pH-responsive hydrogelation
Ryou Kubota, Shogo Torigoe, Shuang Liu, Itaru Hamachi
Chem. Lett. 49, 1319–1323 (2020). DOI: 10.1246/cl.200513
23. Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers
Ryou Kubota, Kazutoshi Nagao, Wataru Tanaka, Ryotaro Matsumura, Takuma Aoyama, Kenji Urayama, Itaru Hamachi
Nature Commun. 11, 4100 (2020). DOI: 10.1038/s41467-020-17984-x
highlighted in Nature Comms Collection on Supramolecular Chemistry
22. Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems
Hajime Shigemitsu*, Ryou Kubota*, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Kenji Urayama, Itaru Hamachi (*: contributed equally)
Nature Commun. 11, 3859 (2020). DOI: 10.1038/s41467-020-17698-0 (open access)
ChemRxiv preprint, DOI: 10.26434/chemrxiv.11626266.v1
highlighted by Kyoto University
21. Force generation by a propagating wave of supramolecular nanofibers
Ryou Kubota, Masahiro Makuta, Ryo Suzuki, Masatoshi Ichikawa, Motomu Tanaka, Itaru Hamachi
Nature Commun. 11, 3541 (2020). DOI: 10.1038/s41467-020-17394-z (open access)
highlighted by Kyoto University
20. Core-shell metal-macrocycle framework (MMF): spatially selective dye inclusion through core-to-shell anisotropic transport along crystalline 1D-channels connected by epitaxial growth
Shohei Tashiro, Shinya Mitsui, David W. Burke, Ryou Kubota, Nobuyuki Matsushita, Mitsuhiko Shionoya
CrystEngComm 22, 1306–1309 (2020). DOI: 10.1039/D0CE00120A
19. The power of confocal scanning laser microscopy in supramolecular chemistry: in situ real-time imaging of stimuli-responsive multicomponent supramolecular hydrogels
Ryou Kubota, Keisuke Nakamura, Shogo Torigoe, Itaru Hamachi
ChemistryOpen 9, 67–79 (2020). DOI: 10.1002/open.201900328
18. pH Nanosensor Using Electronic Spins in Diamond
Takahiro Fujisaku, Ryotaro Tanabe, Shinobu Onoda, Ryou Kubota, Takuya F. Segawa, Frederick T.-K. So, Takeshi Ohshima, Itaru Hamachi, Masahiro Shirakawa, Ryuji Igarashi
ACS Nano 13, 11726–11732 (2019). DOI: 10.1021/acsnano.9b05342
17. Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network
Wataru Tanaka, Hajime Shigemitsu, Takahiro Fujisaku, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi
J. Am. Chem. Soc. 141, 4997–5004 (2019). DOI: 10.1021/jacs.9b00715
16. On-cell coordination chemistry: chemogenetic activation of membrane-bound glutamate receptors in living cells
Ryou Kubota, Shigeki Kiyonaka, Itaru Hamachi
Methods in Enzymology 622, 411–430 (2019). DOI: 10.1016/bs.mie.2019.02.0233
15. Molecular Technologies in Life Innovation: Novel molecular technologies for labeling and functional control of proteins under live cell conditions.
Itaru Hamachi, Shigeki Kiyonaka, Tomonori Tamura, Ryou Kubota
Molecular Technology 2, 294–328 (2018)
14. Rational synthesis of benzimidazole[3]arenes by CuII catalyzed post-macrocyclization transformation
Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya
Chemical Science 9, 7614–7619 (2018). DOI: 10.1039/C(SC03086C (Open access)
13. Chemogenetic approach using Ni(II) complex–agonist conjugates allows selective activation of class A G-protein-coupled receptors
Ryou Kubota, Wataru Nomura, Takuma Iwakasa, Kento Ojima, Shigeki Kiyonaka, Itaru Hamachi
ACS Central Science 4, 1211–1221 (2018). DOI: 10.1021/acscentsci.8b00390 (Open Access)
12. Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators
Ryou Kubota, Shuang Liu, Hajime Shigemitsu, Keisuke Nakamura, Wataru Tanaka, Masato Ikeda, Itaru Hamachi
Bioconjugate Chem. 29, 2058–2067 (2018). DOI: acs.bioconjchem.8b00260 (Open Access)
selected as ACS editors' choice
11. An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks
Hajime Shigemitsu, Takashiro Fujisaku, Wataru Tanaka, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi
Nature Nanotechnol. 13, 165–172 (2018). DOI: 10.1038/s41565-017-0026-6
highlighted in Press release from Kyoto University
10. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions
Shohei Tashiro, Hirotaka Yonezawa, Ryou Kubota, Tsutomu Umeki, Mitsuhiko Shionoya
Chem. Commun. 52, 7657–7660 (2016). DOI: 10.1039/C6CC02621D
9. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells
Shigeki, Kiyonaka*, Ryou Kubota*, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi
Nature Chem. 8, 958-967 (2016) DOI: 10.1038/nchem.2554 (*: contributed equally).
highlighted in Press release from Kyoto University, EurekAlert!, Chem-station
8. In situ real-time imaging of self-sorted supramolecular nanofibres
Shoji Onogi, Hajime Shigemitsu, Tatsuyuki Yoshii, Tatsuya Tanida, Masato Ikeda, Ryou Kubota, Itaru Hamachi
Nature Chem. 8, 743–752 (2016). DOI: 10.1038/nchem.2526
highlighted in News and views, Press release from Kyoto University, EurekAlert!
selected as a front cover
7. Chiral Metal-Macrocycle Frameworks: supramolecular chirality induction and helicity inversion of the helical metal-macrocyclic structures.
Ryou Kubota, Shohei Tashiro, Mitsuhiko Shionoya
Chem. Sci. 7, 2217–2221 (2016). DOI: 10.1039/C5SC04570C
6. Protein recognition using synthetic small-molecular binders toward optical sensing in vitro and in live cells.
Ryou Kubota, Itaru Hamachi
Chem. Soc. Rev. 44, 4454–4471 (2015). DOI: 10.1039/C4CS00381K
5. In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel.
Ryou Kubota, Shohei Tashiro, Motoo Shiro, Mitsuhiko Shionoya
Nature Chem. 6, 913–918 (2014). DOI: 10.1038/nchem.2044
highlighted in 東京大学理学部プレスリリース, Chem-Station
4. Simultaneous arrangement of up to three different molecules on the pore surface of metal-macrocycle framework (MMF): cooperation and competition.
Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya
Angew. Chem. Int. Ed. 53, 8310–8315 (2014). DOI: 10.1002/anie.201404179
Selected as a Frontispiece
3. Palladium- or proton-induced submicro spherical aggregation of macrocyclic amphiphiles in aqueous soluiton.
Shohei Tashiro, Ryou Kubota, Minori Kawagoe, Mitsuhiko Shionoya
Dalton. Trans. 42, 15915–15918 (2013). DOI: 10.1039/C3DT51827B
2. Non-covalent surface modification of metal-macrocycle framework with mono-substituted benzenes.
Ryou Kubota, Shohei Tashiro, Tsutomu Umeki, Mitsuhiko Shionoya
Supramol. Chem. 24, 867–877 (2012). DOI: 10.1080/10610278.2012.733394
1. Metal-macrocycle framework (MMF): supramolecular nano-channel surfaces with shape sorting capability.
Shohei Tashiro, Ryou Kubota, Mitsuhiko Shionoya
J. Am. Chem. Soc. 134, 2461–2464 (2012). DOI: 10.1021/ja209422m
Japanese reviews
9. Self-sorting現象を鍵とする超分子ダブルネットワークゲルの創製
窪田 亮、浜地 格
低分子ゲル・超分子ゲルの設計開発と応用, 117–126 (2023).
8. ガラスのような超分子ネットワーク材料
窪田 亮
化学, 77, 64-65 (2022).
7. 生体分子センシングや薬剤放出の多段階制御を可能とする超分子ヒドロゲル
中村 圭佑、窪田 亮、浜地 格
バイオサイエンスとインダストリー, 79, 2, 103–107 (2021).
6. 細胞から着想を得た多成分系超分子ヒドロゲル
窪田 亮
化学と工業, 73, 950–951 (2020).
5. 蛍光顕微鏡：超分子ポリマーのリアルタイムイメージング
窪田 亮、浜地 格
CSJ Current Review 33 「超分子ポリマー－超分子・自己組織化の基礎から先端材料への応用まで」, 46–49 (2019).
4. 生物を意のままに操る"Chemogenetics"最前線
窪田 亮
生体機能関連化学部会NEWS LETTER, 32, 11–13 (2017).
3. グルタミン酸受容体の選択的活性化を可能とする錯体化学的アプローチ
窪田 亮
生体機能関連化学部会 NEWS LETTER, 31, 3 (2016).
2. 積み上げてつくる多孔性結晶：孤立空間と中空空間のインターフェースを制御する
田代 省平, 窪田 亮, 塩谷 光彦
化学, 67, 64–65 (2012).
1. 非対称な壁面構造を有する単結晶ナノチャネルにおける位置選択的ゲスト分子吸着
窪田 亮
Bull. Jpn. Soc. Coord. Chem. 57, 25–27 (2011).